Minggu, 28 Agustus 2011

[N282.Ebook] Ebook Neil Gaiman's Neverwhere, by Mike Carey

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Neil Gaiman's Neverwhere, by Mike Carey

The comics adaptation of New York Times best-selling author Neil Gaiman's acclaimed novel is now available complete in one 224-page trade paperback! Collecting all nine issues of the Vertigo maxiseries, this volume follows the adventures of an ordinary Londoner who stops to help an enigmatic girl and is drawn into a battle to save the strange underworld kingdom of London Below from destruction.

  • Sales Rank: #153458 in Books
  • Brand: Carey, Mike/ Fabry, Glenn
  • Published on: 2007-02-14
  • Released on: 2007-02-14
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.20" h x .43" w x 6.70" l, .78 pounds
  • Binding: Paperback
  • 224 pages

Most helpful customer reviews

22 of 23 people found the following review helpful.
A victim of 'superhero-itis'
By Byron
As far as the narrative is concerned, this adaptation is fine. The visual interpretation, on the other hand, is so far off Gaiman's descriptions that it's impossible to enjoy. Just seeing how the character of Door is portrayed demonstrates the problem. Gaiman describes her as being small and pixieish, dressed in layers of clothes as well as an oversized leather jacket to 'disappear' into when she is feeling vulnerable. This highly-sexualized version of Door looks more like a refugee from the X-Men by way of Mad Max with her bustier, garterbelt, large breasts and bare midriff on display. The concealing leather jacket has turned into a Matrix-like leather trenchcoat which constantly flaps out behind her. Just because it's fantasy subject matter told in graphic novel form doesn't mean it has to use the visual guidebook of superhero titles where characters are all buff and either wear skintight outfits or show as much skin as possible. I haven't even mentioned the tattoo of a keyhole over her eye. Very subtle. This isn't just a matter of slightly different interpretations. The way the characters are described by Gaiman are part of what defines them and their actions. Very disappointing

12 of 14 people found the following review helpful.
A Failed attempt to improve on the book
By James I. Hales
I tried to read the publication, but couldn't stomach it. It takes the story out of order, removes chapters, and adds dialogue and detail that contradicts the original Novel; it's worse than anything Hollywood could have done to it. Read the original novel. Also, the BBC miniseries isn't bad.

1 of 1 people found the following review helpful.
The Dead & Dying of London Below!
By Critic's Corner
I've never read Neil Gaiman's original novel, but its graphic novel adaptation is an interesting fantasy as told from the viewpoint of a mousy man from London. Richard is a working man, pushed around by his boss, led by the neck from Jessica, his hard-as-nails fiancé. After working 11 hour days he spends his nights eating TV dinners and watching TV.

One day he finds a woman on the streets of London. She's just jumped through a dimensional portal you know, being chased by hit men Croup and Vandemar. He takes her in over the objections of Jessica and nurses Door (yes, that's her name) to health.

In doing so, he becomes an un-person, no one knows he's there. His only hope is to follow Door and hope that he can get his life back, as mundane as it is.

I enjoyed the art by Glenn Fabry very much. The large monster panels of the Beast of London, the large Angel Islington and the realistic blood and the decadent Floating Market are drawn in great detail.

The only thing I did not like was the slow pace of plot. There were not a lot of fight scenes, and not a lot of explanation of the characters and who they were, except for Door. We do learn of Door's family, their power to create doors to anywhere, the ritual slaughter of her family and she, as the survivor, out for vengeance.

The "employer" who hired Croup and Vandemar to kill off Door and her family was revealed mid-novel. And the surprise ending was not all that surprising. The innocence of Richard Mayhew (the story is told from his point of view) does get a bit annoying at times.

Overall, a decent read. I will probably read the original novel and compare to the graphic novel. Writer Mike Carey makes a good point that the graphic novel was never made to be a substitution of the original but to stand on its own as its own story. I can agree to that.

Recommended!

Other Graphic Novels from Neil Gaiman:

Coraline: The Graphic Novel
The Sandman Vol. 1: Preludes and Nocturnes
Coraline Graphic Novel

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Rabu, 24 Agustus 2011

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  • Sales Rank: #15065297 in Books
  • Published on: 2008
  • Original language: English, German
  • Dimensions: 7.80" h x .24" w x 5.08" l,
  • Binding: Paperback

Most helpful customer reviews

0 of 0 people found the following review helpful.
The Queen of Death from John Milne
By Mario
I think the book is especially for young but not advanced readers. Simple vocabulary and sentences are used to relate the story. Despite that, the mistery might interest grown-ups as well. I really enjoyed reading it because the book presents some surprising twists and it has got an exciting plot.

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Sabtu, 06 Agustus 2011

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This Quick Guide covers aspects of drug assessment at the drug discovery and development stages, including pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations.

  • Sales Rank: #1156084 in Books
  • Published on: 2011-04-19
  • Released on: 2011-04-19
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.00" h x .52" w x 5.00" l, .55 pounds
  • Binding: Paperback
  • 214 pages

Review

From the reviews:

“The authors have to be complimented with this comprehensive book of reference on various important topics in the field of pharmacokinetics and drug metabolism. It contains a large collection of figures and tables providing relevant and well-organized information. … In conclusion, this is a valuable reference for workers in the field of pharmacokinetics and drug metabolism, providing a storehouse of information in a comprehensive book.” (Johannes H. Proost, International Journal of Clinical Pharmacology and Therapeutics, Vol. 50 (6), June, 2012)

“The authors intend the book to inform important decisions in a timely fashion ‘for synthesis of superior compounds that have the potential for being a safe and effective drug’. The summary format was designed to be clear, concise and self-explanatory, so it could be used on a daily basis to inform those design decisions. It achieves this goal. It is intended for all drug-discovery scientists, and researchers in all disciplines will certainly find it useful. … In summary, this is a valuable little book.” (Andy Davis, ChemMedChem, Vol. 7, 2012)

“This guide can be used on a day-to-day basis as a useful reference for almost anyone, including students first learning these concepts, as well as scientists in the pharmaceutical industry hoping to apply these principles in their research. … This is a nicely organized quick reference on basic concepts in pharmacokinetics and drug metabolism. It will be a useful addition to the libraries of a variety of readers, from students in the pharmaceutical sciences to accomplished researchers in drug development.”­­­ (Melissa M. Ranieri, Doody's Book Reviews, December, 2011)

From the Back Cover

Drug Metabolism and Pharmacokinetics Quick Guide is intended for broad readership of those interested in the discipline of drug metabolism and pharmacokinetics who work in drug discovery coming from the various disciplines, a background such as of medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics or toxicology.

This guide provides, for the first time, a completely integrated look at multiple aspects of absorption, distribution, metabolism, and excretion (ADME) science in a summary format that is clear, concise and self-explanatory.

This book will be used and referenced frequently as it provides detailed figures and tables for data interpretation. Also included are brief yet relevant factoids that bring a real-world dimension to the discussion of drug metabolism and pharmacokinetics.

Key topics covered:

1. Pharmacokinetics

2. Drug metabolizing enzymes

3. Oral absorption

4. Transporters

5. Metabolism-based drug interactions

6. Biotransformation and bioactivation

7. Prediction of human pharmacokinetics

8. Bioanalysis

9. Physicochemical properties and drug-like properties

10. In silico tools

11. Approved drugs

12. Chemical nomenclature

About the Author

Dr. Siamak Cyrus Khojasteh received his BS from University of California at Berkeley and his PhD from University of Washington in Medicinal Chemistry under the direction of Dr. Sidney D. Nelson.  Dr. Khojasteh leads the Metabolism efforts at Genentech (South San Francisco) and leads a team of about 20 scientists and prior to that he was a Senior Research Scientist at Pfizer (Groton, CT).  His research interest is mechanism of biotransformation particularly with formation of reactive metabolites by P450 or non-P450 enzymes.  

 

Harvey Wong graduated from the University of British Columbia with a Ph.D. in Pharmacokinetics and Biopharmaceutics.  Following graduation, he worked at the DuPont Pharmaceutics Company followed by Bristol-Myers Squibb in the area of Neuroscience Drug Discovery.  Currently, Harvey is a Senior Scientist in the Department of Drug Metabolism and Pharmacokinetics at Genentech, Inc. working in the areas of oncology and immunology.  He is involved in pharmacokinetic modeling and defining preclinical PK-PD relationships for drug candidates in both therapeutic areas. Harvey has published over 70 publications and abstracts.

 

Dr. Cornelis E.C.A. Hop is supervising the Small Molecule Drug Metabolism & Pharmacokinetics Department at Genentech (South San Francisco) and leads a team of about 55 scientists involved in acquisition and interpretation of ADME data in support of drug discovery and development.  Before that he was a senior director at Pfizer (Groton, CT) and a Senior Research Fellow at Merck (Rahway, NJ).  Dr. Hop has extensive experience in ADME sciences and biotransformation, PK prediction and bioanalysis in particular.  He has authored more than 100 publications in refereed journals and several book chapters and made more than 50 external oral presentations at conferences and universities.

Most helpful customer reviews

3 of 4 people found the following review helpful.
Great comprehensive and compact guide
By Amazon Customer
Wonderful guide, very useful as a quick reference or crash course in DMPK. Great coverage of important concepts, thoughtfully written an assembled, and easy to follow for those of us without formal training in pharmacokinetics.

0 of 0 people found the following review helpful.
Quick guide indeed
By nPe
If you wanted to get a start on DMPK, this is an awesome jumping off point. Accurate, current, easy to read and a convenient size for ready access. Wish there was an 'app' like this...

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Senin, 01 Agustus 2011

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  • Sales Rank: #355362 in Books
  • Published on: 2016-01-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.00" h x .47" w x 6.00" l, .63 pounds
  • Binding: Paperback
  • 208 pages

Most helpful customer reviews

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1 of 1 people found the following review helpful.
WILL NEVER BE WITHOUT IT!!!!
By Ben R. Grego
I"ve been buying this annual for many years now........I use the 'best dates' for my dental cleanings, eye exams, and chiropractic treatments....also use it 'slow hair growth" dates.....and every year I give family & friends the best dates to cut their lawns for slow growth.....they razz me about it, but if I don't get it to them early in the season they ask where it is!!! lol...........

Also have a friend with a small bakery business.....there's even a 'best baking dates' list!!!!!! she was skeptical but tried it and was amazed at the results.

so yes, this stuff DOES WORK...............I could never be without it.

I will add, on a sad note, that Ms. Palmer's health is not the best right now.......I spoke to her on the phone a few months ago and she will be turning the almanac over to someone else soon........she also said she's had problems finding a typist to do the work, as it's so involved.....

anyway, GET THIS ALMANAC NOW AN EVERY YEAR.... you'll be amazed at what it can do for you.

I cannot recommend it highly enough!!!!!!!!

2 of 2 people found the following review helpful.
Thanks Lynne Palmer!
By JP
Lynne Palmer's Astrological Almanac is a must have. So happy this is still being made. I have been buying it for about 20 years now. Thanks Lynne Palmer!

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